NEW YORK, March 15 (Xinhua) -- U.S. researchers said
on Sunday they had identified an inherited gene mutation that may be responsible
for certain blood diseases such as myeloproliferative neoplasms.
The research, published online in the British journal
Nature Genetics, found that the inherited alteration in the JAK2 gene is common
in patients who suffered from the overproduction of several types of blood
cells.
"Importantly, patients who inherited this JAK2
alteration were predisposed to acquiring another JAK2 mutation on the same DNA
strand," the researchers at the New York-based Memorial Sloan-Kettering Cancer
Center said in a statement.
"These mutations do not arise randomly, but are
specifically determined by the DNA sequence," they said.
According to the researchers, their findings partly
explain the predisposition for acquiring mutations in certain disease-specific
genes and may help explain why some individuals are at higher risk in developing
the disease.