WASHINGTON, Oct. 28 (Xinhua) -- A novel cell division
mechanism has been discovered in a microorganism that thrives in hot acid,
according to a study published Tuesday in the online version of U.S. journal
PNAS.
The finding may also result in insights into key
processes in human cells, and in a better understanding of the main evolutionary
lineages of life on Earth, said researchers from Uppsala University in Sweden.
The discovery was made in Sulfolobus acidocaldarius,
a microorganism belonging to the third domain of life, the Archaea, which
originally was isolated from a hot spring in Yellowstone national park in the
United States.
Because of the extreme conditions, in which the cells
grow optimally in acid at 80 Centigrade degrees, the organism is of interest for
a wide range of issues, said the article.
They represent exciting model systems in theories for
how life once may have originated in hot environments on early Earth, as well as
in the search for life in extreme environments on other planets, lead researcher
Rolf Bernander explains.
The researchers have identified three genes that are
activated just prior to cell division. The protein products from these genes
form a sharp band in the middle of the cell, between newly segregated
chromosomes, and then gradually constrict the cell such that two new daughter
cells are formed.
This is the first time in decades that a novel cell
division mechanism has been discovered, and the gene products display no
similarity to previously known division proteins, Bernander says.
Two of the three proteins are instead related to
eukaryotic so-called ESCRT-proteins, which play important roles in vesicle
formation during intracellular transport processes, and which also have been
implicated in virus budding, including HIV, from the cell surface.
The results are, thus, important not only for an
increased understanding of the cell biology of archaea and extremophiles, but
also for key cellular processes in human and other higher organisms, and for
issues related to the origin and evolutionary history of these processes, said
the authors.