BEIJING, Feb. 1 (Xinhuanet) -- Medicines
used to treat epilepsy and psychiatric disorders may raise the risk of
suicidal thoughts and behavior, U.S. Food and Drug Administration warned Thursday.
The angency analyzed 199 studies of 11 epilepsy drugs
including Pfizer Inc.'s Neurontin, Novartis AG's Tegretol and Abbott
Laboratories' Depakote
It found that of the 44,000 patients in the study --
28,000 people taking the drugs and 16,000 the placebos, those
who took the drugs had about twice the risk of suicidal behavior compared with
those who took a placebo.
About 0.4 percent of patients given the drugs
reported suicidal thoughts or actions, compared with 0.2 percent of placebo
patients, the FDA said.
This means for every 1,000 patients, about two more
drug-treated patients experienced suicidal thoughts.
"We have just come to the conclusion that it's time
to alert heath-care providers," said FDA spokeswoman Sandy Walsh.
FDA said that the increased risk of suicidality is
expected to be present in all antiepileptic drugs, so it would work with
drug companies to make sure the latest data is reflected in their prescribing
information and labeling.
(Agencies)