BEIJING, June 3 -- American scientists have ushered
in an era of personalized genetics by reading an individual's entire genetic
makeup in record time.
Researchers used a new technique called DNA barcoding
to scan six feet of unravelled genetic material plucked from a single cell of a
donor in two weeks.
The multimillion-dollar Human Genome Project, which
produced the first draft of the human genetic code in 2000, took three years to
complete.
The feat marks the beginning of a dramatic shift in
medicine that will allow people to gaze upon the 6 billion letters that form
their unique biological blueprint for the first time.
David Schwartz, a professor of genetics at the
University of Wisconsin, Madison, will describe the research at the Human Genome
meeting in Helsinki on Saturday. Within three years, he believes his lab will
have a test capable of reading an entire genome within an hour for less than
US$100.
Researchers believe that individualized genetic
printouts will radically improve patients' lives by allowing doctors to give
them personalized advice on their diets, lifestyles and medical check-ups.
Amid the strings of Gs, Ts, Cs and As that make up a
human genome are sequences that reveal not just the colour of our eyes and hair,
but where we came from and what chance we have of developing an endless variety
of diseases and mental impairments.
But Schwartz admitted patients would need counselling
before they are shown the genetic hand they have been dealt.
"Some of this information is going to be hard to
hear, but doctors will have to interpret it in such a way that they can advise
patients on the risks they face without them feeling condemned to a heart attack
or Alzheimer's," he said.
By making genetic tests cheap and easily available,
scientists hope to build unprecedented databases of genetic information that
will reveal precisely the effects of specific genes not just on diseases, but on
personal traits such as character and behaviour.
But moves to use genetic information from individuals
could face stiff opposition from groups who fear the information could fall into
the wrong hands.
"The individual must have as much control over this
information as possible. We don't want to see it abused in any way, for example
by insurance companies," Schwartz said.
To read a whole genome, Schwartz plucks strands of
DNA from a cell and stretches them out on a sheet.
He then squirts on an enzyme that cuts the DNA
whenever it encounters a specific sequence of letters. Studying the barcode-like
pattern produced by the cuts helps identify which letters, or DNA bases, are
where.
Schwartz's team produced six complete genome
sequences using cells from six different people which had been donated
anonymously.
(Source: China Daily)