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New DNA test offers fast reading of genetic makeup
www.chinaview.cn 2006-06-03 09:52:34

    BEIJING, June 3 -- American scientists have ushered in an era of personalized genetics by reading an individual's entire genetic makeup in record time.

    Researchers used a new technique called DNA barcoding to scan six feet of unravelled genetic material plucked from a single cell of a donor in two weeks.

    The multimillion-dollar Human Genome Project, which produced the first draft of the human genetic code in 2000, took three years to complete.

    The feat marks the beginning of a dramatic shift in medicine that will allow people to gaze upon the 6 billion letters that form their unique biological blueprint for the first time.

    David Schwartz, a professor of genetics at the University of Wisconsin, Madison, will describe the research at the Human Genome meeting in Helsinki on Saturday. Within three years, he believes his lab will have a test capable of reading an entire genome within an hour for less than US$100.

    Researchers believe that individualized genetic printouts will radically improve patients' lives by allowing doctors to give them personalized advice on their diets, lifestyles and medical check-ups.

    Amid the strings of Gs, Ts, Cs and As that make up a human genome are sequences that reveal not just the colour of our eyes and hair, but where we came from and what chance we have of developing an endless variety of diseases and mental impairments.

    But Schwartz admitted patients would need counselling before they are shown the genetic hand they have been dealt.

    "Some of this information is going to be hard to hear, but doctors will have to interpret it in such a way that they can advise patients on the risks they face without them feeling condemned to a heart attack or Alzheimer's," he said.

    By making genetic tests cheap and easily available, scientists hope to build unprecedented databases of genetic information that will reveal precisely the effects of specific genes not just on diseases, but on personal traits such as character and behaviour.

    But moves to use genetic information from individuals could face stiff opposition from groups who fear the information could fall into the wrong hands.

    "The individual must have as much control over this information as possible. We don't want to see it abused in any way, for example by insurance companies," Schwartz said.

    To read a whole genome, Schwartz plucks strands of DNA from a cell and stretches them out on a sheet.

    He then squirts on an enzyme that cuts the DNA whenever it encounters a specific sequence of letters. Studying the barcode-like pattern produced by the cuts helps identify which letters, or DNA bases, are where.

    Schwartz's team produced six complete genome sequences using cells from six different people which had been donated anonymously.

    (Source: China Daily)

Editor: Yang Li
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