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WASHINGTON, Feb. 24 (Xinhuanet) -- Studies find a combination of HIV drugs
could better protect babies from contracting the AIDS virus from mothers in
Africa.
Scientists add Combivir to nevirapine, a cheap and highly effective AIDS
drug widely used to prevent mother-to-baby transmission in the Third World. The
drug combinations are intended to work as an alternative to nevirapine, as up to
two-thirds of women have become resistant to the drug.
Combivir contains two HIV drugs called the AZT and 3TC. The drug
combinations appear to have an extremely low rate of resistance.
The findings were presented Thursday in Boston at the 12th Annual
Retrovirus Conference, a meeting of international AIDS researchers.
The drug combinations are considered relatively inexpensive, ata likely
price of more than 30 US dollars a month in a poor country, compared with about
four dollars for a single dose of nevirapine. However, some poor countries
currently cannot even afford nevirapine.
"For a minimum additional cost, we may get many benefits," saidDr. James
McIntyre, an AIDS researcher in South Africa.
In poor countries, nevirapine is usually given in single doses to infected
pregnant women in labor and then to their newborns. This works to reduce the
mother-to-baby transmission of the AIDS virus from about 35 percent to 12
percent.
One of the African studies, conducted in Cote d'Ivoire, found nevirapine
plus Combivir reduced transmission rates at four to sixweeks after birth to
about 5 percent, the lowest ever reported in Africa. And only 1 percent of the
mothers became resistant to nevirapine, and 8 percent to the 3TC.
In the study, nevirapine plus Combivir were given to 329 women during
pregnancy and for three days after birth. The newborns alsotook single-dose
nevirapine and the AZT.
Nearly 40 million people around the world are infected with HIV,65
percent of them living in sub-Saharan Africa. Last year, the AIDS epidemic killed
about 3 million people.
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