BEIJING, Feb. 18 (Xinhuanet) -- Links between popular antidepressants and suicide are unveiled today, showing that taking popular drugs such as Prozac, Paxil and Zoloft are more than twice as likely to attempt suicide as patients given sugar pills.
|Modern antidepressant drugs like Prozac and Seroxat may make patients twice as likely to try to kill themselves than if they were not taking any pills at all.|
The British Medical Journal published three studies on SSRIs (selective serotonin reuptake inhibitors).
Researchers led by Dean Fergusson from the Ottawa Health Research Institute in Canada reviewed 702 studies published since 1967 on SSRIs, a class of drugs that includes Eli Lilly & Co.'s Prozac, Solvay SA's Luvox, GlaxoSmithKline Plc's Paxil, Pfizer Inc.'s Zoloft and Forest Laboratories Inc.'s Celexa and Lexapro.
It found a twofold increase in the risk of a suicide attempt on the drugs.
The second study in the BMJ was carried out by the department of epidemiology of Bristol University. It looked at data from 477 published and unpublished trials submitted to the drugs regulator,
It found no evidence that SSRIs increased the risk of suicide or suicidal thoughts but found some evidence of higher risk for self-harm.
The third study compared people put on SSRIs by their GP for the first time with those given the older antidepressants, called tricyclics. It found no difference in the number of suicides and episodes of self-harm, which the authors say is "reassuring".
The results "should make doctors aware that SSRIs and tricyclics may induce or worsen suicidal behavior during the early phases of treatment," said Andrea Cipriani, a psychiatrist at the University of Verona in Italy and John Geddes, a psychiatrist at Oxford University in a comment. "They should also discourage the routine prescribing of antidepressant drugs in children and adolescents." Enditem